someone explain Zepbound to me like I have not read a paper in years
someone explain Zepbound to me like I have not read a paper in years. I would rather ask a basic question now than get this wrong quietly for two months.
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.
That is everything I have. The rest is opinion and I have tried to keep it out.
best — the order this archive was captured in
The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.
the appetite effect is blunter than sema, in a good way, most weeks
Same experience with the appetite effect being flatter across the week rather than front-loaded.
Left up, flair changed to Discussion. It is an opinion post and that is fine as long as it is labelled.
Same experience with the appetite effect being flatter across the week rather than front-loaded.
Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.
Yes — 10mg being a genuine landing place for a lot of people is underrated. There is no medal for 15.
Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.
SURMOUNT-1 landed around 21% at 72 weeks on the top arm
Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.
Cosigning the four-week thing. It is a minimum interval, and treating it as a schedule to keep up with is how people end up miserable at 12.5.
This matches mine. Milder reflux than I expected, and what there was settled inside a fortnight of each step.
Yes. I stepped to 12.5 because the calendar said so, not because anything needed fixing, and I regretted it for a fortnight.
Disagree with the conversion table. There is no validated equivalence between the two molecules and posting one as though there is does real damage.