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c/tirzepatide·submitted 1 months ago by u/taper_off_tabitha

[Lab] split one vial across PeptideMeter and VendorInvestigate — 98.4% and 97.2%

Labbranch of 7 comments

Posting this because the title is the whole finding — split one vial across PeptideMeter and VendorInvestigate — 98.4% and 97.2% — and a number without its method is a rumour. 98.4% and 97.2%. Those are measured, not estimated, and not rounded up in my favour. The distribution matters more than the mean. In the trial…

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7 comments, started 1 months ago
u/quiet_moderatorMOD200 points·1 months ago

This is the fifth "should I go up" post today and they are all welcome — but no member here can answer it for you.

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u/sanne_novak123 points·1 months ago

This is the fifth "should I go up" post today and they are all welcome — but no member here can answer it for you.

quiet_moderator is right that the two molecules are not interchangeable. There is no published conversion and the ones circulating are invented.

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[removed]75 points·1 months ago

[removed by moderator]

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u/tarek_lokken52 points·1 months ago

It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.

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u/quiet_moderatormod44 points·1 months ago·edited

the appetite effect is blunter than sema, in a good way, most weeks

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u/line_petrov83 points·1 months ago

Vials and pens carry the same molecule; what differs is fill volume, device tolerance and whether you are doing your own arithmetic. Neither is inherently more accurate.

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u/tidy_vialdrawer_pls-37 points·1 months ago

The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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