anyone else notice GIP kicking in around week 81
anyone else notice GIP kicking in around week 81, logged the same way every week so the comparison is at least internally fair. Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it. The distribution matters more than the mean. In the trial…
week 6 is early to draw any conclusion at all
week 6 is early to draw any conclusion at all
Agreed, with one qualifier: that is the mean of the top arm and the spread around it was enormous.
Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.
the trials titrated on a calendar, real people titrate on symptoms
stepping every four weeks is a ceiling on speed, not a schedule you must hit
Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.
if 7.5 is working, 10 is not automatically better
Held 7.5 for five months. Everyone kept asking when I was going to 10. The answer was never, because 7.5 was working.
Cosigning the four-week thing. It is a minimum interval, and treating it as a schedule to keep up with is how people end up miserable at 12.5.
Agreed, and the trial number is a mean of a very wide distribution — the tails are enormous and nobody posts from the middle.
2.5mg is a four-week starting dose, not a maintenance dose. Worth being precise since people search these threads.