someone explain metformin to me like I have not read a paper in years
The title is the whole question — someone explain metformin to me like I have not read a paper in years — but here is why I am asking. A1c reflects average glycaemia over roughly the preceding three months, weighted towards the most recent weeks. It cannot show variability and it lags any change you make. On…
Retitled — the original quoted an obesity endpoint as a glycaemic one.
That is a sensor value, not a plasma value, and the two are not interchangeable at that level of precision.
Push back: one sensor reading is not a data point worth acting on, especially in the first day of wear.
time in range is the more informative number and it is newer
Brought the whole CGM export to my appointment rather than one number. Entirely different conversation.
check the trial population before quoting a result at somebody
Continuous monitoring shows the shape: postprandial excursions, overnight behaviour and time in range. Two people with identical A1c can have very different distributions.