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c/survodutide·submitted 10 months ago by u/thermal_mass_tom

my ALT moved and I cannot work out whether dual agonist is why

Discussionbranch of 9 comments

Something I keep coming back to: my ALT moved and I cannot work out whether dual agonist is why. Imaging-derived liver fat fraction is a surrogate. It correlates with histology imperfectly, and a trial reporting one is not reporting the other. Nothing containing this compound is approved anywhere. Research-use-only…

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9 comments, started 10 months ago
u/elin_tamm164 points·10 months ago

Looked for independent results across this whole site and found almost none. Worth knowing before forming an opinion.

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u/kaia_wojcik0 points·10 months ago

Looked for independent results across this whole site and found almost none.

Agreed — and the endpoint definitions are where the actual claim lives.

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u/hana_lehtinen1 point·10 months ago

Correction: that is the imaging endpoint, not the histological one. The paper reports both and they differ substantially.

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u/vikram_mbeki113 points·10 months ago

Are you reading the publication or a summary?

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