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c/retatrutide·submitted 6 months ago by u/iman_castellanos

is it normal to get fatigue at week 5

Resultsbranch of 7 comments

is it normal to get fatigue at week 5. Numbers below. Ask me the boring questions, they are the useful ones. It is a triple agonist at the GLP-1, GIP and glucagon receptors. The glucagon arm is the genuinely novel component and it is the one with the least human outcome data behind it. Increases in heart rate have…

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7 comments, started 6 months ago
u/fabio_lehtinen692 points·6 months ago

Glucagon receptor agonism is associated with increased energy expenditure and with hepatic effects. That is a mechanistic story with strong preclinical support and limited phase 2 human data.

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u/incretin_ivyMOD397 points·6 months ago

Removed the escalation schedule. There is no published protocol for members to follow and inventing one here is exactly what this board does not do.

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[removed]263 points·6 months ago

[removed by moderator]

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u/iman_castellanosOP282 points·6 months ago

comparing reta phase 2 to sema phase 3 is comparing different things

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u/kofi_balogun130 points·6 months ago

comparing reta phase 2 to sema phase 3 is comparing different things

Agreed, and the glucagon arm is exactly why the comparison threads do not work.

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u/noor_ivaturi273 points·6 months ago

Correction: TRIUMPH is the phase 3 programme. The number you are quoting is from the phase 2 readout, which is a different trial.

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u/emil_wojcik178 points·6 months ago

Yes — the glucagon arm is what makes it a different proposition rather than a stronger version of the others.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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