is it normal to get fatigue at week 5
is it normal to get fatigue at week 5. Numbers below. Ask me the boring questions, they are the useful ones.
It is a triple agonist at the GLP-1, GIP and glucagon receptors. The glucagon arm is the genuinely novel component and it is the one with the least human outcome data behind it.
Increases in heart rate have been reported across this receptor class. The magnitude and clinical significance are exactly what phase 3 is powered to establish.
Please do not ask me what dose you should be on. I genuinely do not know and neither does anyone else here.
best — the order this archive was captured in
Glucagon receptor agonism is associated with increased energy expenditure and with hepatic effects. That is a mechanistic story with strong preclinical support and limited phase 2 human data.
Removed the escalation schedule. There is no published protocol for members to follow and inventing one here is exactly what this board does not do.
comparing reta phase 2 to sema phase 3 is comparing different things
comparing reta phase 2 to sema phase 3 is comparing different things
Agreed, and the glucagon arm is exactly why the comparison threads do not work.
Correction: TRIUMPH is the phase 3 programme. The number you are quoting is from the phase 2 readout, which is a different trial.
Yes — the glucagon arm is what makes it a different proposition rather than a stronger version of the others.
the escalation is where most of the reported trouble sits
the TRIUMPH programme is still running, so anything definitive is premature
The phase 2 readout ran to 48 weeks in a few hundred participants with a slow escalation. Both the size and the duration matter when people quote the headline number.
Where the evidence actually stands, since every thread here assumes a different answer.
Phase 2 reported a large mean body weight change at 48 weeks across a few hundred participants with a slow, protocol-driven escalation. The effect size was striking. The confidence intervals were wide, the population was small, and the duration was under a year.
Phase 3 is running. Until it reports, everything else — including the ranking arguments this board loves — is extrapolation from a small study. That is not a criticism of the compound; it is a description of the evidence.
wait for phase 3 before you argue about rankings
nothing here is available as a prescription product, so read every thread with that in mind
- 1Glucagon receptor agonism is associated with increased energy expenditure…7 comments in this branch · started by u/fabio_lehtinen