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c/retatrutide·submitted 5 months ago by u/ferran_krastev

[Lab] WXT reta — PeptideMeter came back 97.1% against a claimed 97.0%

Labbranch of 10 comments

Short version of the title, which is already short: WXT reta — PeptideMeter came back 97.1% against a claimed 97.0%. Longer version underneath. Figures up front so nobody has to dig: 97.1% and 97.0%. The standing caveat, written out properly because it keeps getting compressed into a footnote. Nothing containing this…

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10 comments, started 5 months ago
u/incretin_ivypharmacology304 points·5 months ago

heart rate is the thing people report watching

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u/ferran_krastevOP438 points·5 months ago

heart rate is the thing people report watching

Disagree with this specific inference. A 48-week readout does not tell you the shape of the curve after it.

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[removed]310 points·5 months ago

[removed by moderator]

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u/lina_bruun216 points·5 months ago

What is the source for that figure — the published paper or a summary of it?

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u/zeynep_mbeki258 points·5 months ago

Kept a log specifically because there is so little published. It is one person and it is not data.

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u/titration_marshalmod · c/semaglutide0 points·5 months ago

Sceptical of the extrapolation. Forty-eight weeks does not tell you about seventy-two, and the curve shape is exactly what is unknown.

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u/sofia_wikstrom1 point·5 months ago

Sceptical of the extrapolation.

titration_marshal is right about the escalation being the variable. It explains most of the difficult reports here.

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u/nordic_pricing1 point·5 months ago

How fast was the escalation? That is usually the variable that explains the reports.

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u/marit_laurent1 point·5 months ago

Phase 2 estimates effect and finds a dose range. Phase 3 estimates it precisely in a bigger population and catches what phase 2 was too small to see. Treating them as the same tier of evidence is the recurring error here.

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u/ewan_zielinski1 point·5 months ago

Phase 2 estimates effect and finds a dose range.

Adding the standing caveat: none of this is approved anywhere and research material is not for human use.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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