dose escalation — my 2-week log, condensed into one table
Posting this as a discussion rather than a claim: dose escalation — my 2-week log, condensed into one table. Phase 2 estimates effect and finds a dose range. Phase 3 estimates it precisely in a bigger population and catches what phase 2 was too small to see. Treating them as the same tier of evidence is the recurring…
Nothing containing this compound is approved anywhere. Research-use-only material is not approved for human use, and that is a statement of fact rather than a disclaimer.
Went up slowly, deliberately, because everything on this board says the escalation is where trouble lives. Uneventful so far and I am not going to pretend that is a finding.
dose escalation in the trials was slow for a reason
The fatigue profile felt different rather than worse. Hard to describe and impossible to quantify, so take it as an impression.
Kept a log specifically because there is so little published. It is one person and it is not data.
the energy-expenditure story is mechanistically interesting and clinically unproven
Correction: TRIUMPH is the phase 3 programme. The number you are quoting is from the phase 2 readout, which is a different trial.
research-use-only material is not approved for human use, full stop