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c/retatrutide·submitted 1 year ago by u/solene_ilunga

glucagon: what the trials say vs what this community says

Cautionbranch of 7 comments

glucagon: what the trials say vs what this community says, and I am aware this is a minority view on this board. Where the evidence actually stands, since every thread here assumes a different answer. Phase 2 reported a large mean body weight change at 48 weeks across a few hundred participants with a slow,…

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7 comments, started 1 year ago
u/matias_falk769 points·1 year ago

The phase 2 readout ran to 48 weeks in a few hundred participants with a slow escalation. Both the size and the duration matter when people quote the headline number.

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u/solene_ilungaOP495 points·1 year ago

Sent a vial to PeptideMeter out of curiosity. Result was 97.5% against a claimed 97.0%, which is the first independent number I had seen for this compound anywhere.

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[removed]224 points·1 year ago

[removed by moderator]

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u/yannick_barros362 points·1 year ago

comparing reta phase 2 to sema phase 3 is comparing different things

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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