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c/retatrutide·submitted 2 years ago by u/customs_seizure_sid

what would you tell week-1 you about dose escalation

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The title is the whole question — what would you tell week-1 you about dose escalation — but here is why I am asking. It is a triple agonist at the GLP-1, GIP and glucagon receptors. The glucagon arm is the genuinely novel component and it is the one with the least human outcome data behind it. The standing caveat,…

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8 comments, started 2 years ago
u/ferran_krastev42 points·2 years ago

Same read. The energy-expenditure mechanism is the interesting bit and it is not established in humans at scale.

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u/aa_analysis_andy10 points·2 years ago

dose escalation in the trials was slow for a reason

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u/reta_and_regret3 points·2 years ago

the TRIUMPH programme is still running, so anything definitive is premature

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[deleted]17 points·2 years ago

[deleted]

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u/mod_cold_roommod · c/coldchain9 points·2 years ago

Agreed, and the framing that helps is: this is a phase 2 compound with phase 3 running. Everything else is inference.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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