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c/retatrutide·submitted 1 year ago by u/quiet_moderator

[Results] 57 weeks, 25kg, and glucagon was the hard part

Resultsbranch of 7 comments

57 weeks, 25kg, and glucagon was the hard part, logged the same way every week so the comparison is at least internally fair. Hard numbers: 57 weeks and 25kg. Anything softer than that is flagged as an impression. It is a triple agonist at the GLP-1, GIP and glucagon receptors. The glucagon arm is the genuinely novel…

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7 comments, started 1 year ago
u/baseline_drifteranalytical350 points·1 year ago

Same read. The energy-expenditure mechanism is the interesting bit and it is not established in humans at scale.

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u/nabila_bakken161 points·1 year ago

Agreed on the heart-rate reports. They are consistent enough across the threads to be worth noting, not enough to be a finding.

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u/liver_enzyme_liz130 points·1 year ago

heart rate is the thing people report watching

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u/arne_amankwah156 points·1 year ago

This. The phase 2 result was genuinely large and it was also 48 weeks in a few hundred people.

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u/burned_once_twice53 points·1 year ago

triple agonist — GLP-1, GIP and glucagon, and the glucagon arm is the new part

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[deleted]60 points·1 year ago

[deleted]

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u/titration_marshalmod · c/semaglutide16 points·1 year ago

phase 2 data only, and people quote it like it is a label

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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