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c/retatrutide·submitted 2 years ago by u/naomi_erdogan

am I the only one who found glucagon harder than the injections

Cautionbranch of 7 comments

am I the only one who found glucagon harder than the injections. I am not trying to be the "source?" guy. I would just like a source. Increases in heart rate have been reported across this receptor class. The magnitude and clinical significance are exactly what phase 3 is powered to establish. Phase 2 estimates…

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7 comments, started 2 years ago
u/careful_gradient_again362 points·2 years ago

Watched heart rate on a wearable across twelve weeks because the threads said to. It moved a little and I have no idea whether that means anything.

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u/yannick_barros178 points·2 years ago

Disagree. "More receptors means more effect" is not how any of this works and the trial data does not support the linear story.

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u/careful_gradient_again62 points·2 years ago

the phase 2 numbers were striking and they were also 48 weeks in a small population

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u/ledger_modmod · vetting107 points·2 years ago·edited

Disagree.

yannick_barros is right about the escalation being the variable. It explains most of the difficult reports here.

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u/marta_vanhecke25 points·2 years ago

triple agonist — GLP-1, GIP and glucagon, and the glucagon arm is the new part

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u/nabila_bakken18 points·2 years ago

How fast was the escalation? That is usually the variable that explains the reports.

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u/trialwatch_theotrial nerd119 points·2 years ago

the escalation is where most of the reported trouble sits

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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