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Single comment threadYou are looking at one branch of my A1c moved and I cannot work out whether TRIUMPH is why — 33 comments in the full submission. View in context.
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c/retatrutide·submitted 9 months ago by u/andres_sorensen

my A1c moved and I cannot work out whether TRIUMPH is why

Cautionbranch of 11 comments

Thinking out loud about this: my A1c moved and I cannot work out whether TRIUMPH is why. Nothing containing this compound is approved anywhere. Research-use-only material is not approved for human use, and that is a statement of fact rather than a disclaimer. Independent purity testing on this compound is thin…

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11 comments, started 9 months ago
u/nikhil_lindqvist26 points·9 months ago

Same read. The energy-expenditure mechanism is the interesting bit and it is not established in humans at scale.

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u/marta_vanhecke8 points·9 months ago

Right, and it bears repeating that nothing here is approved anywhere and research material is not for human use.

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u/andres_sorensenOP14 points·9 months ago

The thing that surprised me was how much of the discussion here is inference rather than measurement.

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u/marit_laurent3 points·9 months ago

Are you comparing against phase 3 numbers for something else? They are not comparable.

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u/yannick_barros2 points·9 months ago

the glucagon component is why the metabolic story reads differently

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u/andres_sorensenOP6 points·9 months ago

How fast was the escalation? That is usually the variable that explains the reports.

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u/sofia_wikstrom7 points·9 months ago·edited

Agreed on the heart-rate reports. They are consistent enough across the threads to be worth noting, not enough to be a finding.

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u/rui_only_ro2 points·9 months ago

a lot of the confident posting here is extrapolation

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u/nabila_bakken20 points·9 months ago

Careful with the rankings. A phase 2 result and a phase 3 result are not on the same evidential footing and cannot be listed in one table.

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u/arne_amankwah-5 points·9 months ago

small trial, big effect, wide error bars

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u/reta_and_regret1 point·9 months ago

Has anyone posted an independent test on this compound recently?

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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