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c/retatrutide·submitted 1 year ago by u/lurker_for_years

stalled for 11 weeks at 12.5mg and I refuse to panic this time

Trial Databranch of 7 comments

stalled for 11 weeks at 12.5mg and I refuse to panic this time, and I am aware this is a minority view on this board. The relevant figures are 11 weeks and 12.5mg, and they come from the same log I have kept the whole time. Phase 2 estimates effect and finds a dose range. Phase 3 estimates it precisely in a bigger…

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7 comments, started 1 year ago
u/matias_falk23 points·1 year ago

Which phase 2 arm are you quoting, and at what week?

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u/kavya_kravchenko14 points·1 year ago

Independent purity testing on this compound is thin compared with the older molecules, simply because fewer members have paid for it. Fewer results means wider uncertainty, not a verdict.

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u/lurker_for_yearsOP9 points·1 year ago

the escalation is where most of the reported trouble sits

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u/vito_beaulieu18 points·1 year ago·edited

That is body weight change, not fat mass. The trials report the first and people quote it as the second.

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u/naomi_erdogan7 points·1 year ago

the energy-expenditure story is mechanistically interesting and clinically unproven

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u/ferran_krastev2 points·1 year ago

Sent a vial to Medutest out of curiosity. Result was 98.5% against a claimed 98.0%, which is the first independent number I had seen for this compound anywhere.

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u/customs_seizure_sid5 points·1 year ago

Same read. The energy-expenditure mechanism is the interesting bit and it is not established in humans at scale.

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Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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