stalled for 17 weeks at 2.5mg and I refuse to panic this time
stalled for 17 weeks at 2.5mg and I refuse to panic this time. I have gone back and forth on this for months.
17 weeks and 2.5mg — those are the numbers, and they are the ones I am willing to defend.
Independent purity testing on this compound is thin compared with the older molecules, simply because fewer members have paid for it. Fewer results means wider uncertainty, not a verdict.
Went up slowly, deliberately, because everything on this board says the escalation is where trouble lives. Uneventful so far and I am not going to pretend that is a finding.
Tell me where this is wrong. That is the useful part of posting it.
best — the order this archive was captured in
Phase 2 estimates effect and finds a dose range. Phase 3 estimates it precisely in a bigger population and catches what phase 2 was too small to see. Treating them as the same tier of evidence is the recurring error here.
The constipation profile felt different rather than worse. Hard to describe and impossible to quantify, so take it as an impression.
The phase 2 readout ran to 48 weeks in a few hundred participants with a slow escalation. Both the size and the duration matter when people quote the headline number.