[Discussion] we are measuring appetite at the wrong time and calling it noise
Thinking out loud about this: we are measuring appetite at the wrong time and calling it noise. The GIP question, which is the most interesting unsettled thing in this field. Dual agonism at GIP and GLP-1 receptors produces clinical results that are robust and well replicated. What is not settled is the mechanism by…
I would not read that in vitro number across to a person. The conditions are nothing like physiological.
This. Albumin binding and modification are why the half-life is what it is, and it is a design decision rather than an accident.
incretin effect first, then everything else in this board makes sense
albumin binding is most of the half-life story
Was completely wrong about the gastric emptying story in a thread here two years ago. Someone corrected me with a citation and I have not made that mistake since.
Disagree. That is a preclinical finding in a rodent model and you are stating it as human pharmacology.
Disagree.
Adding the caveat the paper itself makes in its limitations section, which is stronger than anything in this thread.
the peripheral and central stories are not in competition