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c/glp1science·submitted 2 months ago by u/elin_lundgren

incretin: what the trials say vs what this community says

Speculationbranch of 6 comments

incretin: what the trials say vs what this community says. Making the case below, and I expect to lose some of it in the comments. Long half-life in this class comes from structural modification that promotes albumin binding and resists enzymatic degradation. Weekly dosing is a consequence of the molecule, not a…

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6 comments, started 2 months ago
u/gastric_emptying_gMOD130 points·2 months ago

Speculation is welcome here if it is labelled. This one has been relabelled rather than removed.

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u/tomas_broberg107 points·2 months ago

Do you have the paper, or a summary of it?

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u/elin_lundgrenOP-14 points·2 months ago

Which receptor arm are you attributing that to?

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u/laila_almeida40 points·2 months ago

mechanism explains a direction, not a magnitude

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u/asks_dumb_questions40 points·2 months ago

Same view. Tolerance developing to the gastric effect while the appetite effect persists explains most of what the side-effect board reports.

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u/bilal_osei44 points·2 months ago

Agreed that receptor distribution is the key to the side-effect map. It is not a mystery, it is anatomy.

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