biased agonism: real, interesting, almost certainly irrelevant to your dose
biased agonism: real, interesting, almost certainly irrelevant to your dose. I have gone back and forth on this for months.
Was completely wrong about the gastric emptying story in a thread here two years ago. Someone corrected me with a citation and I have not made that mistake since.
Receptor expression in a tissue is necessary but not sufficient for an effect. You also need the agonist to reach it at relevant exposure, and that is where a lot of confident mechanism talk falls down.
Read the primary paper after arguing about the summary for a fortnight. The discussion section said almost the opposite of what the thread had concluded.
Please do not ask me what dose you should be on. I genuinely do not know and neither does anyone else here.
best — the order this archive was captured in
GIP receptor biology is genuinely unsettled — there is a live argument about agonism versus antagonism at the receptor — and the clinical results are robust regardless, which is an uncomfortable and interesting position.
Small fix — it slows gastric emptying, it does not halt it, and the distinction matters for the mechanism you are proposing.
Yes. The discussion section is where the authors say what they actually think, and almost nobody here reads it.
Right — mechanism gives you a direction. It never gives you an effect size and people use it as though it does.
Agreed that receptor distribution is the key to the side-effect map. It is not a mystery, it is anatomy.
Left up and flaired Explainer. This is the standard of post the board was created for.
Went looking for human data on a mechanism everybody here asserts. Found preclinical work and one small study. That was clarifying.
This. Albumin binding and modification are why the half-life is what it is, and it is a design decision rather than an accident.
incretin effect first, then everything else in this board makes sense
Spent an evening on the receptor distribution literature and the side-effect map suddenly stopped looking random.
mechanism explains a direction, not a magnitude