[Explainer] delayed gastric emptying does most of the work people credit to the brain
delayed gastric emptying does most of the work people credit to the brain. If you already knew this, the post is not for you and you can scroll on. Started reading limitations sections first. It has changed how much weight I give to almost everything posted here. Asked a question here that I thought was stupid and…
Long half-life in this class comes from structural modification that promotes albumin binding and resists enzymatic degradation. Weekly dosing is a consequence of the molecule, not a convenience decision.
Does the effect persist with continued dosing or does tolerance develop?
Tolerance to the gastric effect develops with continued exposure while the appetite effect largely persists. That single fact explains most of the "it settles but it still works" pattern the side-effect board reports.
incretin effect first, then everything else in this board makes sense
Asked for a citation rather than removing. On this board a claim without one is an invitation, not an offence.
receptor distribution is why the side effects are where they are
Which receptor arm are you attributing that to?
What does the discussion section say about the limitation you are glossing?