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c/glp1science·submitted 10 days ago by u/nurse_ish_2025

[Discussion] we use "appetite suppression" to describe three different mechanisms

Discussionbranch of 6 comments

we use "appetite suppression" to describe three different mechanisms. It is the sort of thing everyone half-believes and nobody writes down. Started reading limitations sections first. It has changed how much weight I give to almost everything posted here. Asked a question here that I thought was stupid and got three…

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6 comments, started 9 days ago
u/second_week_sceptic-4 points·9 days ago

Are we talking about receptor affinity or clinical potency?

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u/nurse_ish_2025OP1 point·9 days ago

Was completely wrong about the gastric emptying story in a thread here two years ago. Someone corrected me with a citation and I have not made that mistake since.

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u/nadia_fonseca1 point·8 days ago

What was the exposure in that experiment relative to therapeutic?

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u/farid_kuipers1 point·8 days ago

receptor agonism is not the same as receptor activation in every tissue

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u/nurse_ish_2025OP1 point·9 days ago

Does the effect persist with continued dosing or does tolerance develop?

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u/nurse_ish_2025OP-5 points·9 days ago

Is there any human data on that mechanism yet?

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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