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c/compounding·submitted 1 year ago by u/hassan_chowdhury

three years of 503A threads, summarised so you do not have to read them

Discussionbranch of 9 comments

three years of 503A threads, summarised so you do not have to read them — a position I have arrived at slowly and would like tested. Why "compounded" is not "generic", written out because the confusion is constant. A generic is an approved product demonstrated to be bioequivalent to a reference. A compounded…

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9 comments, started 1 year ago
u/prior_auth_painappeals434 points·1 year ago

On concentration, which is where I see people actually get hurt.

A compounded vial can be filled at a different concentration from the branded product you were previously using. If you carry over your old arithmetic — same number of units, different mg/mL — you draw a different amount and may not notice for weeks.

Read the label every time you switch. Redo the arithmetic on paper. Write the concentration on the vial. It is the same habit c/reconstitution keeps preaching and this is the case where it actually bites.

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u/neha_krastev117 points·1 year ago

Agreed on potency testing of the finished preparation. That is a different question from the purity of the starting material.

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u/ferran_mensah63 points·1 year ago

That figure is the starting material purity, not the finished preparation potency. Two different tests.

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u/rohan_steiner55 points·1 year ago

shortage status changes and the whole arrangement changes with it

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u/ireland_drugs_pay127 points·1 year ago

The intake asked me three questions and none of them were about my history. That told me everything I needed to know about the model.

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u/jonas_eriksen41 points·1 year ago

potency testing on the finished preparation is the thing to ask for

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u/priya_palacios101 points·1 year ago·edited

On concentration, which is where I see people actually get hurt.

prior_auth_pain is right about the concentration trap. It breaks arithmetic that has been reliable for months.

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u/hassan_chowdhuryOP191 points·1 year ago

the API source is the question nobody asks and everybody should

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u/lukas_vermeulen88 points·1 year ago

compounded is not generic, there is no equivalence claim

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About c/compounding

Compounded GLP-1s as a supply route: the 503A/503B distinction, the shortage-list mechanics that made compounding legal and then didn't, state board rules, telehealth prescriber models, and what a compounding pharmacy will and will not tell you about its API source.

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