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c/bloodwork·submitted 2 months ago by u/constipation_club

the bloodwork thing finally clicked for me and I want to write it down

Resultsbranch of 7 comments

the bloodwork thing finally clicked for me and I want to write it down. Not a hot take, just something I have not seen said plainly here. ApoB counts atherogenic particles rather than the cholesterol they carry, which is why it can diverge from LDL-C and why it is the addition most worth making. Why so many single…

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7 comments, started 2 months ago
u/emil_okwuosa189 points·2 months ago

Different laboratories use different assay platforms with different calibration. Comparing across labs adds a systematic offset that is invisible on the report.

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u/freya_baptista-8 points·2 months ago

ApoB is the one worth adding if you only add one

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u/nikhil_asante1 point·2 months ago

do not change three things and then read the panel

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u/bac_water_banditreconstitution1 point·2 months ago

Yes — same lab, same fasting state, same rough time of day, or the comparison is doing nothing.

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u/constipation_clubOPside effects68 points·2 months ago

Is that the same assay, or did the lab change platforms?

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u/hugo_pires53 points·2 months ago

fasting state and time of day change more than people expect

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u/emeka_chowdhury15 points·2 months ago

fasting state and time of day change more than people expect

Agreed — and standardising the draw conditions is the cheapest improvement available.

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What to measure before you start, what to re-measure, and how to interpret movement without panicking. ApoB over LDL-C, HOMA-IR as a crude free tool, ALT and the fatty-liver story, eGFR noise during rapid loss, and the deficiencies that a 1,100-calorie appetite will hand you.

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