[Concerning] ferritin 9. i was eating 1,100 calories and calling it discipline.
The title is the argument: ferritin 9. i was eating 1,100 calories and calling it discipline. Here is the rest of it.
Reference intervals are typically the central 95% of a reference population. By construction one person in twenty falls outside one on any given test without anything being wrong.
The confounding problem, stated plainly, because this board keeps stepping on it.
Substantial weight loss moves lipids, liver enzymes, insulin sensitivity markers and several others in its own right. If you are losing weight while taking something, any change in those markers has at least two candidate explanations and you cannot separate them from your own panel.
What you can do is standardise, take a baseline, keep the series long, and be honest in your posts about what is and is not attributable. The threads that say "this compound did X to my ALT" almost never have the design to support the claim, mine included.
Repeat testing before acting is standard practice for a reason: regression to the mean does a lot of work on single outlying values.
Sceptical readings welcome. The confident ones are the ones I distrust.
best — the order this archive was captured in
Different laboratories use different assay platforms with different calibration. Comparing across labs adds a systematic offset that is invisible on the report.
Standing reminder: nobody here interprets your results, and posts asking us to get a pointer to somebody who can.
draw at the same point in the week if you want comparability
Yes. Repeat before you react. Almost every alarming single value I have posted here regressed on the repeat.
Is that the same assay, or did the lab change platforms?
Is that the same assay, or did the lab change platforms?
This is the sentence to read before anybody panics about a single value.
This. Reference ranges are population intervals, not targets, and conflating them causes a lot of unnecessary alarm here.
Do you have a baseline from before you started?
My hs-CRP moved and I spent a fortnight convinced I knew why. The repeat six weeks later was back in range and I had changed nothing.
That is a non-fasting value and the interval you are comparing it against is a fasting one.
Why so many single values look alarming and turn out to be nothing.
A reference interval is built to contain about 95% of a healthy reference population, so one test in twenty falls outside one by construction. Add biological variation, assay imprecision, fasting state and time of day, and a genuinely stable person will produce occasional out-of-range results.
That is why repeat testing before acting is standard. Regression to the mean handles most of it. None of which means an out-of-range value should be ignored — it means it should be repeated and taken to somebody who can put it in context, which is emphatically not a ranked feed.
Yes — same lab, same fasting state, same rough time of day, or the comparison is doing nothing.
Substantial weight loss independently moves lipids, liver enzymes and several other markers. Attributing a change to a compound while losing weight is confounded by design.
one measurement is a point, two is a line, three is a trend
ApoB is the one worth adding if you only add one
- 1Different laboratories use different assay platforms with different…6 comments in this branch · started by u/ferran_halonen