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c/bloodwork·submitted 2 years ago by u/karl_fischer_kev

[Discussion] can we stop arguing about ApoB until somebody posts a number

Discussionbranch of 10 comments

Question in the title, detail here: can we stop arguing about ApoB until somebody posts a number. Reference intervals are typically the central 95% of a reference population. By construction one person in twenty falls outside one on any given test without anything being wrong. Different laboratories use different…

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10 comments, started 2 years ago
u/whois_wanda218 points·2 years ago

Substantial weight loss independently moves lipids, liver enzymes and several other markers. Attributing a change to a compound while losing weight is confounded by design.

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u/transit_variance53 points·2 years ago

Repeat testing before acting is standard practice for a reason: regression to the mean does a lot of work on single outlying values.

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u/karl_fischer_kevOP40 points·2 years ago

lab reference ranges are not treatment targets

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u/jonas_cardoso63 points·2 years ago

Nobody here can interpret your panel and this comment is not doing so. What a board can usefully do is help you ask better questions of somebody who can.

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u/ismael_eriksen39 points·2 years ago

Panicked about a single result, posted here, got told to repeat it, repeated it, and it was fine.

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u/kofi_balogun21 points·2 years ago·edited

Small fix — a reference interval is not a treatment target, and the post above uses them interchangeably.

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u/a1c_arcT2D15 points·2 years ago

This. Reference ranges are population intervals, not targets, and conflating them causes a lot of unnecessary alarm here.

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u/chidi_abubakar6 points·2 years ago

the trend line matters more than any single value

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u/intent_to_treat2 points·2 years ago

a single ApoB outside range is a reason to repeat, not to panic

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u/andres_restrepo91 points·2 years ago

Agreed on assay changes. A lab switching platforms between your draws is invisible unless you ask.

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About c/bloodwork

What to measure before you start, what to re-measure, and how to interpret movement without panicking. ApoB over LDL-C, HOMA-IR as a crude free tool, ALT and the fatty-liver story, eGFR noise during rapid loss, and the deficiencies that a 1,100-calorie appetite will hand you.

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