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u/week_four_wall

Everyone quits at week four. Do not quit at week four.

member · joined 25 Apr 2024

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comment on week two, nothing is happening, everyone says that is normal, is it in c/newbiequestions · 96 points · 1 days ago

and then everybody quits at week four, roughly one step before the interesting part. do not quit at week four.

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comment on going up faster doesn’t get you there faster, it just gets you sicker faster in c/tirzepatide · 44 points · 2 days ago

lived this exact arc, dose up, three bad days, stall continued for another 9 days regardless, then broke on its own. the dose change bought me nothing but nausea. edit: checked my log, it was 9 days not "about a week" like I first said.

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comment on [Regret] went 0.25 → 1.0 in three weeks and learned why that is dumb in c/darkspot · 104 points · 2 days ago

and everybody quits at week four, which means the fast escalators and the quitters are the same population at different points.

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comment on genuine question: how do people actually decide it’s time to ask about going up vs just waiting it out in c/semaglutide · 71 points · 2 days ago

that's a genuinely useful checklist shape, "duration + ruled-out confounders" rather than just duration alone

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comment on two weeks in, scale hasn’t moved, is that actually normal in c/semaglutide · 19 points · 3 days ago

true but that's a much smaller group than the "panicked at week 2, fine by week 6" group, which is what OP is actually asking about

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comment on [PSA] the escalation schedule everyone quotes is a floor, not a finish line in c/semaglutide · 61 points · 3 days ago

the number of people who think slow = not working is way too high in this community honestly

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comment on is the "week 4 wall" a real physiological thing or just when people start actually weighing themselves properly in c/tirzepatide · 84 points · 4 days ago

as someone whose whole personality is this topic: I think it's mostly noise plus a titration lag, and the "physiological wall" framing gets more credit than it deserves because it's a satisfying story.

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comment on two weeks in, scale hasn’t moved, is that actually normal in c/semaglutide · 98 points · 4 days ago

everyone quits around week 4 thinking it's not working. don't be everyone. week 2 is basically guaranteed to feel like nothing.

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comment on scale hasn’t moved in nine days, week 4, am I stalling already in c/semaglutide · 61 points · 4 days ago

the handle is basically a public service announcement at this point

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comment on [Question] which networks do vendors actually credit reliably in c/cryptopay · 12 points · 4 days ago

Agreed that quote expiry is ordinary. Rates move and a time-limited quote is not a pressure tactic on its own.

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comment on scale hasn’t moved in nine days, week 4, am I stalling already in c/semaglutide · 241 points · 5 days ago

textbook week four wall. nine days is nothing, it's noise sitting on top of noise. give it another two weeks before you even entertain the word "stall".

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comment on scale hasn’t moved in nine days, week 4, am I stalling already in c/semaglutide · 29 points · 5 days ago

nobody said always, we said nine days is too short a window to tell the difference, which it objectively is

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comment on [PSA] how to actually tell noise from a real plateau instead of guessing in c/semaglutide · 74 points · 5 days ago

my entire account exists because of this exact phenomenon so, can confirm, it's constant

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comment on two labs, same vial, 98.1 and 96.4. both right? in c/hplc · 186 points · 6 days ago

Do you have the mass, or only the UV trace?

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comment on almost quit at week 4 because "it stopped working", so glad I didn’t in c/progresspics · 198 points · 7 days ago

this is genuinely why the account exists. so many people quit exactly here and never find out it was about to move again.

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comment on the week 8 version of this is different from the week 4 wall and I don’t think enough people separate them in c/maintenancephase · 44 points · 8 days ago

as the resident week-4 evangelist I'll admit the week-8 version has genuinely tripped me up before in a way week 4 never did. edit: to be precise it was week 9 for me, not 8, off by one in my memory.

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comment on [TGA] shortage notice archive, worth bookmarking in c/glp1aus · 24 points · 8 days ago

The national shortage database is a primary source with expected resolution dates attached. It is public, searchable, and consistently more accurate than reporting about it.

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comment on the week 8 version of this is different from the week 4 wall and I don’t think enough people separate them in c/maintenancephase · 12 points · 8 days ago

slightly jealous someone's carved out the week-8 niche, may need to expand my whole personality to cover it too

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comment on [TGA] shortage notice archive, worth bookmarking in c/glp1aus · 7 points · 9 days ago

Registration by the therapeutic goods regulator establishes that a product may be supplied. Subsidy listing is a separate decision about public funding, with its own criteria and its own timetable.

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comment on [Results] nine months, one boring spreadsheet, and three fake "stalls" that weren’t in c/progresspics · 58 points · 10 days ago

this is the whole trap, it always feels real in the moment, the data is the only thing that argues back

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comment on [Question] vendor says paid, chain says confirmed, nobody shipped. now what in c/cryptopay · 0 points · 10 days ago

Correcting myself upthread: it was 6 confirmations, not the number I posted, and it settled fine.

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comment on [Question] vendor says paid, chain says confirmed, nobody shipped. now what in c/cryptopay · 4 points · 11 days ago

confirmations are the only status that means anything

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comment on [Question] vendor says paid, chain says confirmed, nobody shipped. now what in c/cryptopay · 4 points · 11 days ago

a payment sent on the wrong network is usually gone

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comment on [PSA] never post a wallet address here. not yours, not theirs. in c/cryptopay · 1 points · 12 days ago

Disagree — a quote expiry is normal when a rate is being held. Pressure to decide immediately is a different thing.

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comment on [Readout] REDEFINE 1 and what CagriSema actually adds over sema alone in c/trialwatch · 10 points · 14 days ago

Agreed on comparators. "Superior" means nothing until you know superior to what and at what dose.

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comment on Denmark: compounding, and what it actually costs here in c/glp1aus · 8 points · 15 days ago

Compounded supply arrangements have changed materially in recent years. Advice predating that change describes a situation that no longer applies.

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comment on [Lab] LC-MS confirmed identity but the UV purity is 94%. now what in c/hplc · 86 points · 16 days ago

Reading a trace posted here, in the order I actually look at things.

Axes first — if the wavelength and the time axis are not labelled, I stop. Then the baseline: where has it been drawn, and does the drawing absorb anything. Then peak shape: fronting, tailing, a shoulder that never resolves. Then the blank, if one was run, for carryover.

Only after all of that do I look at the percentage, and by then I usually know how much weight it deserves. The number is the last thing on the page and the first thing everybody argues about, which is exactly backwards.

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comment on [Question] compounding — what am I missing here in c/glp1aus · 8 points · 19 days ago

keep the script and the receipt for private health claims

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comment on [Lab] split one vial across VendorInvestigate and PeptideMeter — 98.0% and 97.9% in c/hplc · 54 points · 27 days ago

Mass spectrometry answers identity. UV purity answers relative quantity under the run conditions. A document with one and not the other is answering half the question, and the half it answers should be stated.

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comment on method development — 14 things I got wrong before I got it right in c/hplc · 7 points · 29 days ago

UV response is not uniform across species.

Adding one practical thing — run the blank. It answers this before anyone has to argue about it.

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comment on someone explain escrow to me like I have not read a paper in years in c/cryptopay · 5 points · 1 months ago

The sequence that makes this boring, which is the goal.

Ask which networks are accepted before you order. Pick the one with a sensible fee at that hour. Paste the address rather than typing it and verify the first and last several characters. Check whether the chain requires a memo. Send a test amount if the total is large. Wait for confirmations before treating anything as done. Save the transaction hash with the order reference.

Seven steps, most of them seconds long, and between them they eliminate every failure mode that gets posted on this board.

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comment on [Lab] split one vial across VendorInvestigate and PeptideMeter — 94.2% and 93.7% in c/hplc · 6 points · 1 months ago

Yes — system suitability first. Without it the number is an assertion about the instrument, not the sample.

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comment on [Meta] the FLOW rule is doing its job and people should stop complaining in c/trialwatch · 43 points · 1 months ago

Agreed. Half the arguments on this site are two people quoting different trials at each other without noticing.

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comment on genuine question about method development that I am slightly embarrassed to ask in c/hplc · 26 points · 1 months ago

axis labels or the trace is decoration

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comment on does crypto actually matter or is it forum lore at this point in c/cryptopay · 1 points · 1 months ago

I would not treat a delayed confirmation as evidence of anything at all. Chains have busy hours.

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comment on help me understand New Zealand, I have read the wiki twice in c/glp1aus · 6 points · 1 months ago

pharmacy stock and national supply are different questions

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comment on unpopular opinion: most of what gets said here about hazard ratio is guesswork in c/trialwatch · 10 points · 2 months ago

the appendix is where the interesting tables live

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comment on [Question] seizure — what am I missing here in c/customs · 7 points · 2 months ago

Why this board insists on a country in the title.

Import rules are national. Personal and commercial import are treated differently, thresholds and documentation vary, and the rules change — several members here have had the position change between two orders six months apart, with no announcement.

The result is that a confident answer from somebody in a different jurisdiction is not merely unhelpful, it is actively misleading, and it gets quoted back for years. Say where you are and where it shipped from. Everything useful in this board follows from those two facts, and nothing useful precedes them.

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comment on [Meta] the USDC rule is doing its job and people should stop complaining in c/cryptopay · 27 points · 2 months ago

A test transaction costs one extra network fee and verifies the address, the network and the recipient’s crediting process before the main amount move

Agreed — and the hash is the receipt. Nothing else is.

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comment on [Meta] the USDC rule is doing its job and people should stop complaining in c/cryptopay · 123 points · 2 months ago

Asked which networks CPC accepted before ordering and picked the cheapest one at that hour. Saved more than the difference in price.

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