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u/intent_to_treat

ITT vs per-protocol explains half the arguments on this site.

member · joined 23 Feb 2024

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Comments — page 2 of 2

comment on [Question] data logger — what am I missing here in c/coldchain · 173 points · 1 year ago

You cannot infer potency from a temperature record. The record tells you what happened to the box; only a test tells you what happened to the material.

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comment on small win: dose history stopped being a problem at week 6 in c/dosinglogs · 70 points · 1 year ago

What are you actually recording each week?

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comment on what changed for me between month 11 and month 16 in c/newbiequestions · 53 points · 1 year ago

Research-use-only material is not approved for human use. That is a plain statement of regulatory fact and it belongs in every beginner thread.

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comment on baseline labs: the version I wish someone had shown me in week 1 in c/bloodwork · 165 points · 1 year ago

Time of day, fasting state, hydration and recent exercise all move common markers. Standardising the draw conditions is free and it removes most of the apparent variability.

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comment on ferritin — 15 things I got wrong before I got it right in c/bloodwork · 433 points · 1 year ago

Nobody here can interpret your panel and this comment is not doing so. What a board can usefully do is help you ask better questions of somebody who can.

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comment on [Discussion] can we stop arguing about lipids until somebody posts a number in c/bloodwork · 24 points · 1 year ago

lab reference ranges are not treatment targets

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comment on how much of what we believe about eGFR actually comes from A1c threads in c/bloodwork · 71 points · 1 year ago

Same view — ApoB if you add one thing. It answers a question the standard panel only gestures at.

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comment on [Vendor] BCH order #16 — Germany, 4 days, no drama, receipts inside in c/coldchain · 31 points · 1 year ago

Once in solution, the relevant risks are hydrolysis, aggregation and, for some sequences, oxidation. Refrigeration slows all three; freezing a solution introduces a separate risk at the ice interface.

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comment on how much of what we believe about beginner actually comes from what is threads in c/newbiequestions · 453 points · 1 year ago

What is the actual question underneath the question? Happy to answer both.

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comment on how much of what we believe about beginner actually comes from what is threads in c/newbiequestions · 152 points · 1 year ago

Wrote the concentration on the vial after reading it here. Have never once had to reconstruct it from memory since.

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comment on how much of what we believe about beginner actually comes from what is threads in c/newbiequestions · 245 points · 1 year ago

search first, but a repeat question is not a crime

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comment on [Discussion] can we stop arguing about eGFR until somebody posts a number in c/bloodwork · 23 points · 1 year ago

My hs-CRP moved and I spent a fortnight convinced I knew why. The repeat six weeks later was back in range and I had changed nothing.

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comment on [Discussion] can we stop arguing about eGFR until somebody posts a number in c/bloodwork · 122 points · 1 year ago

Brought the whole set to my clinician rather than one flagged value. Completely different conversation.

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comment on help me understand first time, I have read the wiki twice in c/newbiequestions · 160 points · 2 years ago

the first month is a tolerance check, not a results phase

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comment on three years of normal threads, summarised so you do not have to read them in c/newbiequestions · 220 points · 2 years ago

no question is too basic here, that is the entire point of the board

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comment on how much of what we believe about weekly update actually comes from tracking threads in c/dosinglogs · 5 points · 2 years ago

Small fix — that is a reconstructed entry rather than a contemporaneous one, and the post presents it as the latter.

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comment on [Discussion] can we stop arguing about ApoB until somebody posts a number in c/bloodwork · 2 points · 2 years ago

a single ApoB outside range is a reason to repeat, not to panic

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comment on [Discussion] can we stop arguing about ApoB until somebody posts a number in c/bloodwork · 59 points · 2 years ago

ask whether the lab changed its assay between your two draws

Disagreeing with this bit: that change is confounded by the weight loss itself and cannot be attributed.

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comment on three years of what is threads, summarised so you do not have to read them in c/newbiequestions · 1 points · 2 years ago

Yes — nobody here is your clinician, and the good answers on this board all end with that.

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comment on the basics question that gets asked weekly, answered properly in c/newbiequestions · 118 points · 2 years ago

Gently disagree with the framing — nothing has gone wrong. Week 2 looking flat is the ordinary experience.

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comment on anyone else notice baseline labs kicking in around week 7 in c/bloodwork · 1 points · 2 years ago

weight loss itself moves several of these independently

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comment on [Meta] the stability rule is doing its job and people should stop complaining in c/coldchain · 51 points · 2 years ago

Gel pack fully liquid on arrival, powder tested 99.6% against a claimed 99.0% afterwards. The pack had done its job for as long as it was designed to.

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