STEP

the placebo arm lost weight too. always ask by how much — a position I have arrived at slowly and would like tested. Why comparing across trials almost never works,…

number needed to treat, or i am not interested, and I am aware this is a minority view on this board. Read a press release and the publication three months apart. The…

Question in the title, detail here: how much of what we believe about endpoint actually comes from FLOW threads. Went looking for the registered protocol to see whether…

step therapy — how do i document failing something cheaper. I would rather ask a basic question now than get this wrong quietly for two months. Asked for the policy…

the FLOW rule is doing its job and people should stop complaining. Nothing about this affects the ranking maths, before anyone asks. On means, which this board treats…

The title is the argument: the endpoint advice in here is 3 years out of date. Here is the rest of it. To save the first four comments: 3 years. On means, which this…

how do you actually verify SURPASS — that is what I am asking, and I have already read the wiki twice. Started keeping the trial identifiers straight in a note file…

Question in the title, detail here: help me understand step therapy, I have read the wiki twice. New plan year, entirely new criteria, and the denial that had been…

The one-line version is the title: write the concentration on the vial. that is the whole post. The rest is why. Intention-to-treat analyses everybody randomised…

Posting the boring version of a titration log because I wish I'd had one with this much unremarkable detail before I started. Weeks 1–4: starter dose, mild fatigue day…

Posting this as a discussion rather than a claim: watch where the curves separate, not just whether they do. Relative risk reduction without the baseline rate is…

the STEP thing finally clicked for me and I want to write it down. Not a hot take, just something I have not seen said plainly here. Spent an evening with the appendix…

Asking properly rather than in a comment on somebody else’s thread: why does nobody talk about SELECT. Compared myself to a trial mean for about six months before…

how much of what we believe about endpoint actually comes from SURPASS threads. I am not trying to be the "source?" guy. I would just like a source. Read a press…

SURMOUNT-4 withdrawal arm, read the appendix not the abstract. Change my mind, genuinely — I have no stake in being right about this. Started keeping the trial…

the STEP thing finally clicked for me and I want to write it down. Change my mind, genuinely — I have no stake in being right about this. On means, which this board…

The title is the argument: FLOW got published and nobody in here is talking about eGFR slope. Here is the rest of it. Intention-to-treat analyses everybody randomised…

Posting this as a discussion rather than a claim: TRIUMPH is doing more work than we give it credit for. Why comparing across trials almost never works, with the…

Slightly embarrassed to be asking this, but: what the STEP 4 and SURMOUNT-4 withdrawal arms actually showed. The habits are what carried it for a while. When they…

The title is the argument: the step therapy thing finally clicked for me and I want to write it down. Here is the rest of it. New plan year, entirely new criteria, and…

The title is the argument: unpopular opinion: most of what gets said here about step therapy is guesswork. Here is the rest of it. New plan year, entirely new criteria,…

intent-to-treat vs per-protocol explains half the arguments on this site. Change my mind, genuinely — I have no stake in being right about this. On means, which this…

step therapy is doing more work than we give it credit for. Not a hot take, just something I have not seen said plainly here. Step therapy requires documented trial of…

unpopular opinion: most of what gets said here about hazard ratio is guesswork. Not a hot take, just something I have not seen said plainly here. A confidence interval…

Posting this as a discussion rather than a claim: SURPASS — 7 things I got wrong before I got it right. Compared myself to a trial mean for about six months before…