glucagon

stalled for 12 weeks at 10mg and I refuse to panic this time. It is the sort of thing everyone half-believes and nobody writes down. 12 weeks and 10mg — those are the…

is it normal to get sulphur burps at week 87. Full detail below, and I have tried to keep the editorialising out of it. Stopped at a low step because there was no…

went too fast on reta and my resting HR told me before i noticed. Change my mind, genuinely — I have no stake in being right about this. Read the phase 2 paper twice…

three years of retatrutide threads, summarised so you do not have to read them. It is the sort of thing everyone half-believes and nobody writes down. Glucagon receptor…

genuine question about MASH that I am slightly embarrassed to ask. I would rather ask a basic question now than get this wrong quietly for two months. Asked here what…

Thinking out loud about this: stalled for 7 weeks at 10mg and I refuse to panic this time. 7 weeks and 10mg — those are the numbers, and they are the ones I am willing…

Short version of the title, which is already short: 24th independent test on QSC — 98.4% on a claimed 98.0%, and the trend is the interesting part. Longer version…

anyone else notice triple agonist kicking in around week 65. Numbers below. Ask me the boring questions, they are the useful ones. Kept a log specifically because there…

biopsy is the most under-discussed thing on this board. I have gone back and forth on this for months. Phase 2 in a biopsy-confirmed population is a demanding design:…

the glucagon arm is why the appetite effect feels different — a position I have arrived at slowly and would like tested. Watched heart rate on a wearable across twelve…

three years of survodutide threads, summarised so you do not have to read them. Not a hot take, just something I have not seen said plainly here. Histological endpoints…

glucagon receptor agonism raising energy expenditure — how solid is that. Making the case below, and I expect to lose some of it in the comments. Asked a question here…

is it normal to get muscle cramps at week 85. Same spreadsheet I have been keeping since the start, nothing retrofitted. Phase 2 estimates effect and finds a dose…

Slightly embarrassed to be asking this, but: why does nobody talk about biopsy. Bought small because the evidence base is early. That is the only defensible position I…

Thinking out loud about this: phase 2 biopsy endpoints, and what "resolution" means. The honest evidence position, written out so this board does not drift. Phase 2…

stalled for 8 weeks at 1.7mg and I refuse to panic this time. Making the case below, and I expect to lose some of it in the comments. Since the title puts numbers in…

glucagon is doing more work than we give it credit for. It is the sort of thing everyone half-believes and nobody writes down. Glucagon receptor agonism is associated…

we are measuring TRIUMPH at the wrong time and calling it noise. Making the case below, and I expect to lose some of it in the comments. The constipation profile felt…

stalled for 11 weeks at 12.5mg and I refuse to panic this time, and I am aware this is a minority view on this board. The relevant figures are 11 weeks and 12.5mg, and…

week 32 check-in — 14kg down, nausea manageable, one thing confusing me, and the part I actually want to talk about is at the bottom. Numbers, in the order they matter:…

Slightly embarrassed to be asking this, but: someone explain biopsy to me like I have not read a paper in years. Bought small because the evidence base is early. That…

hepatic fat is doing more work than we give it credit for. Making the case below, and I expect to lose some of it in the comments. Imaging-derived liver fat fraction is…

Posting this as a discussion rather than a claim: the TRIUMPH advice in here is 2 years out of date. Figures up front so nobody has to dig: 2 years. Sent a vial to…

is it normal to get constipation at week 7, logged the same way every week so the comparison is at least internally fair. Assumed the weight numbers were the point and…

Check-in as promised in the title: small win: hepatic fat stopped being a problem at week 91. Nothing containing this compound is approved anywhere. Research-use-only…