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c/tirzepatide·submitted 1 months ago by u/hana_pereira

the Zepbound question that gets asked weekly, answered properly

Trial Databranch of 9 comments

the Zepbound question that gets asked weekly, answered properly, and I am aware this is a minority view on this board. Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it. 26kg over 66 weeks, never went past 10mg, and muscle cramps stayed mild the…

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9 comments, started 1 months ago
u/britt_okwuosa252 points·1 months ago·edited

Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.

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u/emil_wojcik102 points·1 months ago

Not sure that follows. You went up a step and changed your training in the same fortnight.

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u/amara_halonen38 points·1 months ago

Right. And the sema-to-tirz "conversion" people post is invented. There is no published equivalence.

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u/zeynep_ndiaye32 points·1 months ago

2.5 is the starter dose and it is not meant to be the dose that works

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u/hana_pereiraOP14 points·1 months ago

What is the waist doing? That is usually the number still moving during a scale stall.

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u/ferran_mensah4 points·1 months ago

Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.

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u/ferran_mensah50 points·1 months ago

Disagree with the conversion table. There is no validated equivalence between the two molecules and posting one as though there is does real damage.

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u/zeynep_zielinski34 points·1 months ago

That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.

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u/zaid_balogun34 points·1 months ago

2.5mg is a four-week starting dose, not a maintenance dose. Worth being precise since people search these threads.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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