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c/tirzepatide·submitted 1 months ago by u/search_before_post

am I the only one who found Mounjaro harder than the injections

Side Effectsbranch of 7 comments

The title is the whole question — am I the only one who found Mounjaro harder than the injections — but here is why I am asking. The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week. Went 10 to 12.5 on the calendar and had the worst fortnight of the…

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7 comments, started 1 months ago
u/cormac_pereira327 points·1 months ago

The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.

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u/ferran_mensah106 points·1 months ago

Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.

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u/tidy_vialdrawer_pls93 points·1 months ago

the trials titrated on a calendar, real people titrate on symptoms

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u/search_before_postOP57 points·1 months ago

Have you held a step for longer than the four-week minimum at any point?

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u/sofia_nascimento13 points·1 months ago

Which week did the appetite change actually land for you?

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u/search_before_postOP8 points·1 months ago

What is the waist doing? That is usually the number still moving during a scale stall.

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u/search_before_postOP254 points·1 months ago

Pen or vial? The step sizes available differ and it changes this answer.

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Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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