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c/tirzepatide·submitted 9 months ago by u/dario_vermeulen

[Question] is 99.3% actually fine or am I being sold a rounding error

Questionbranch of 7 comments

The claim in the title is exactly the claim I am making: is 99.3% actually fine or am I being sold a rounding error. Nothing implied beyond it. Pulling the figures out of the title: 99.3%. All of it is written down as it happened rather than reconstructed. The step schedule question, answered properly, because it…

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7 comments, started 9 months ago
u/swirl_dont_shakereconstitution84 points·9 months ago

The 21% figure is a 72-week mean on the highest arm. Quoting it as what someone should expect by week 18 is not a fair reading.

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u/ingrid_correia58 points·9 months ago

The 21% figure is a 72-week mean on the highest arm.

swirl_dont_shake is right that the two molecules are not interchangeable. There is no published conversion and the ones circulating are invented.

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u/line_petrov34 points·9 months ago

swirl_dont_shake is right that the two molecules are not interchangeable.

Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.

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u/titration_marshalmod · c/semaglutide17 points·9 months ago

stepping every four weeks is a ceiling on speed, not a schedule you must hit

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u/nordic_pricing8 points·9 months ago

a lot of people plateau nicely at 10mg and never need 15

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u/matias_salgado-16 points·9 months ago

the trials titrated on a calendar, real people titrate on symptoms

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u/ferran_mensah21 points·9 months ago

dual agonist, so the GIP arm is doing something the sema threads will not tell you about

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Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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