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c/tirzepatide·posted 2 months ago by u/two_mil_or_one

small win: Mounjaro stopped being a problem at week 45

Question

small win: Mounjaro stopped being a problem at week 45. This is a description of what happened to me and not a plan for anybody else.

Vials and pens carry the same molecule; what differs is fill volume, device tolerance and whether you are doing your own arithmetic. Neither is inherently more accurate.

The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.

I will update this if the picture changes rather than quietly leaving it up.

129 up / 198 down39% upvoted11 commentsid 1sn0lm1 May 2026

11 comments

11 in this archive, depth 5

best — the order this archive was captured in

u/matias_salgado10 points·2 months ago·edited

The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.

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u/fatima_wojcik6 points·2 months ago

It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.

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u/emil_wojcik1 point·2 months ago·edited

SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.

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u/two_mil_or_oneOP1 point·2 months ago

Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it.

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u/forest_plot_fionastats1 point·2 months ago

Have you held a step for longer than the four-week minimum at any point?

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u/bastian_ekstrom0 points·2 months ago

Have you held a step for longer than the four-week minimum at any point?

Agreed, with one qualifier: that is the mean of the top arm and the spread around it was enormous.

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[deleted]2 points·2 months ago

[deleted]

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u/two_mil_or_oneOP1 point·2 months ago

Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.

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u/samir_falk0 points·2 months ago

Yes. I stepped to 12.5 because the calendar said so, not because anything needed fixing, and I regretted it for a fortnight.

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u/endpoint_creep2 points·2 months ago

zepbound and mounjaro are the same compound with different labels

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u/dario_stanescu4 points·2 months ago

Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.

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Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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