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c/tirzepatide·submitted 8 months ago by u/ferritin_low

switched from 5mg to 15mg and constipation got better, not worse

Labbranch of 6 comments

Thinking out loud about this: switched from 5mg to 15mg and constipation got better, not worse. Hard numbers: 5mg and 15mg. Anything softer than that is flagged as an impression. The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week. Appetite effect…

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6 comments, started 8 months ago
u/rania_diallo374 points·8 months ago

The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.

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u/sten_bhattacharya-25 points·8 months ago

Not sure that follows. You went up a step and changed your training in the same fortnight.

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u/signe_villalobos-29 points·8 months ago

sulphur burps are the signature complaint and they are not dangerous

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u/customs_seizure_sid521 points·8 months ago

Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.

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u/nordic_pricing337 points·8 months ago

Correction to my own post above — I said 15mg and I have been on 2.5mg since the spring. Same argument, wrong number.

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u/copay_card_cc615 points·8 months ago

Held 7.5 for five months. Everyone kept asking when I was going to 10. The answer was never, because 7.5 was working.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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