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c/tirzepatide·posted 6 days ago by u/marta_dziedzic

[Lab] SSA tirz 10mg — Janoshik 99.1%, third batch in a row

Lab

SSA tirz 10mg — Janoshik 99.1%, third batch in a row, and before anyone asks: same batch throughout, single submission, no cherry-picking between services.

10mg and 99.1%. Those are measured, not estimated, and not rounded up in my favour.

Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.

Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it.

Tell me where this is wrong. That is the useful part of posting it.

114 up / 5 down96% upvoted12 commentsid 1om2rl23 Jul 2026
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12 comments

12 in this archive, depth 5

best — the order this archive was captured in

u/neha_falk12 points·6 days ago

Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.

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u/samir_falk7 points·6 days ago

Right. And the sema-to-tirz "conversion" people post is invented. There is no published equivalence.

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u/mikkel_ogunleye3 points·6 days ago

The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.

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u/hair_shed_hannah5 points·5 days ago

the appetite effect is blunter than sema, in a good way, most weeks

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u/marit_sandvik4 points·4 days ago·edited

SURMOUNT-1 landed around 21% at 72 weeks on the top arm

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u/kaia_cabrera3 points·4 days ago

Yes. I stepped to 12.5 because the calendar said so, not because anything needed fixing, and I regretted it for a fortnight.

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[removed]2 points·4 days ago

[removed by moderator]

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u/certified_referenceQC1 point·4 days ago

Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.

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u/halima_boateng1 point·3 days ago

Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state.

certified_reference is right that the two molecules are not interchangeable. There is no published conversion and the ones circulating are invented.

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u/piotr_nascimento2 points·4 days ago

Disagree with the conversion table. There is no validated equivalence between the two molecules and posting one as though there is does real damage.

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u/matias_salgado2 points·4 days ago

Cosigning the four-week thing. It is a minimum interval, and treating it as a schedule to keep up with is how people end up miserable at 12.5.

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u/certified_referenceQC1 point·4 days ago

hold the dose that works, the ladder is not a leaderboard

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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