[Results] 5mg for eight months, never went higher, -22kg
5mg for eight months, never went higher, -22kg. Posting the boring middle of the process, because the internet is full of the start and the end and nothing else.
Numbers, in the order they matter: 5mg and 22kg.
Switching from semaglutide, since three people asked in this thread alone.
There is no published dose equivalence between the two. The conversion tables that circulate are somebody’s arithmetic, not data. What people report here is that the first month after a switch is often flat, that the appetite effect feels differently shaped rather than simply stronger, and that starting at the bottom of the ladder again is the common approach.
None of that is a recommendation. It is what the threads say, and the threads are not a clinic.
On comparing yourself with the trial number.
SURMOUNT-1 reported roughly 21% mean body weight change at 72 weeks on the highest arm. Three things get dropped every time that figure is quoted here. It is a mean, and the distribution around it is very wide. It is 72 weeks, which is a year and a half. And it is a trial population with trial support, which is not the same as a person with a spreadsheet.
Use it as a rough shape, not a benchmark. A 12% year is inside the ordinary range and people quit over it every week on this board.
Would rather be corrected in public than confident in private.
best — the order this archive was captured in
The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.
switching from sema is not a dose conversion, there is no clean equivalence
Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
Trial identifiers corrected in the title. SURMOUNT and SURPASS are different programmes.
2.5mg is a four-week starting dose, not a maintenance dose. Worth being precise since people search these threads.
hold the dose that works, the ladder is not a leaderboard
Pen or vial? The step sizes available differ and it changes this answer.
The 21% figure is a 72-week mean on the highest arm. Quoting it as what someone should expect by week 72 is not a fair reading.