[Meta] the SURPASS rule is doing its job and people should stop complaining
the SURPASS rule is doing its job and people should stop complaining, and here is what changes in practice if it goes ahead. SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category…
The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.
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pens and vials are the same molecule, the price is the difference
I would separate the two claims. That the GIP arm exists is uncontroversial; that it explains your nausea pattern is a guess.
Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.
The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.
Trial identifiers corrected in the title. SURMOUNT and SURPASS are different programmes.
switching from sema is not a dose conversion, there is no clean equivalence
Did you come to this from sema, and if so how long was the gap?
Pen or vial? The step sizes available differ and it changes this answer.
Pen or vial?
Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.
2.5 is the starter dose and it is not meant to be the dose that works
Are you comparing yourself with the trial mean or with the people who post the most?
the constipation profile is genuinely gentler than people expect coming from sema
6kg over 21 weeks, never went past 10mg, and fatigue stayed mild the whole way. Posting because the loud threads are all 15mg.
6kg over 21 weeks, never went past 10mg, and fatigue stayed mild the whole way.
hub_ops is right that the two molecules are not interchangeable. There is no published conversion and the ones circulating are invented.
dual agonist, so the GIP arm is doing something the sema threads will not tell you about