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c/tirzepatide·submitted 2 years ago by u/rania_diallo

unpopular opinion: most of what gets said here about GIP is guesswork

Trial Databranch of 9 comments

unpopular opinion: most of what gets said here about GIP is guesswork. Making the case below, and I expect to lose some of it in the comments. SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two…

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This branch

9 comments, started 2 years ago
u/sanne_novak91 points·2 years ago

the appetite effect is blunter than sema, in a good way, most weeks

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u/aksel_kjaer48 points·2 years ago

2.5 is the starter dose and it is not meant to be the dose that works

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u/crosspost_bot_no24 points·2 years ago

Agree. The GIP component is the interesting half and it barely gets discussed outside c/glp1science.

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u/rania_dialloOP48 points·2 years ago

What step are you on and how long have you been there?

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u/quiet_moderatormod70 points·2 years ago

What step are you on and how long have you been there?

Agreed, with one qualifier: that is the mean of the top arm and the spread around it was enormous.

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u/thyroid_tangent39 points·2 years ago

Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.

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u/curious_panel_only32 points·2 years ago

Does early fullness follow the day after the shot, or is it spread across the week?

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u/rania_dialloOP24 points·2 years ago

What is the waist doing? That is usually the number still moving during a scale stall.

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u/customs_seizure_sid7 points·2 years ago

Not sure that follows. You went up a step and changed your training in the same fortnight.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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