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c/tirzepatide·submitted 2 years ago by u/spain_receta

[Question] tirzepatide — what am I missing here

Questionbranch of 9 comments

tirzepatide — what am I missing here. If this has been answered properly somewhere, link me and I will delete. Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled. Came off sema and onto tirz with a two-week gap. The first month was flat and I…

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9 comments, started 2 years ago
u/quiet_moderatormod516 points·2 years ago

the appetite effect is blunter than sema, in a good way, most weeks

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u/amara_halonen366 points·2 years ago

It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.

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u/spain_recetaOP282 points·2 years ago

It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads.

Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.

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u/blunt_coldbox29133 points·2 years ago

Not sure about this bit.

Saving this one. It is the clearest statement of the stall problem I have read here.

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u/ahmed_fonseca64 points·2 years ago

pens and vials are the same molecule, the price is the difference

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u/spain_recetaOP282 points·2 years ago

Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.

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u/cormac_pereira331 points·2 years ago

Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.

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u/aurel_lindqvist95 points·2 years ago

the trials titrated on a calendar, real people titrate on symptoms

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u/sten_bhattacharya220 points·2 years ago

hold the dose that works, the ladder is not a leaderboard

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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