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c/t2dglp1·submitted 8 months ago by u/arne_nyberg

[Discussion] can we stop arguing about T2D until somebody posts a number

Discussionbranch of 13 comments

can we stop arguing about T2D until somebody posts a number. I am not trying to be the "source?" guy. I would just like a source. Postprandial excursions typically respond earlier than fasting glucose, so the sequence people observe is not a sign that something is not working. Sensor accuracy varies across wear, and…

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13 comments, started 8 months ago
u/joaquin_stanescu92 points·8 months ago

postprandial excursions are where most of the improvement shows up first

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u/sock_puppet_spotter135 points·8 months ago

The three numbers, and what each one can and cannot tell you.

A1c is an average over about three months, weighted to the recent weeks. It cannot show variability and it lags change. Continuous monitoring shows the shape — excursions, overnight, time in range — and is where improvement usually becomes visible first. Fingersticks are point measurements, useful for sanity-checking a sensor and for specific questions.

Most of the frustrated posts here come from expecting one of the three to answer a question that belongs to another. And all three are inputs to a conversation with whoever manages your care, which is not this board.

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u/wanjiru_osei93 points·8 months ago

That is a sensor value, not a plasma value, and the two are not interchangeable at that level of precision.

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u/rania_marchand31 points·8 months ago

the diabetes trials report different endpoints from the obesity ones

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u/arne_nybergOP17 points·8 months ago

What does time in range look like, not just the average?

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u/arne_nybergOP0 points·8 months ago

How long between the two A1c measurements?

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u/tomas_lundgren62 points·8 months ago

glycaemic control and weight are two different endpoints

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u/arne_nybergOP37 points·8 months ago

check the trial population before quoting a result at somebody

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u/plain_titration30 points·8 months ago

A1c, CGM, or fingersticks — which are we discussing?

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u/amylin_amyamylin37 points·8 months ago

Agreed on variability. Two people with the same average can have completely different days.

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u/sock_puppet_spotter20 points·8 months ago·edited

Correction: that trial is the diabetes programme and the figure you quoted is its glycaemic endpoint, not a weight result.

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u/chidi_abubakar13 points·8 months ago

Correction: that trial is the diabetes programme and the figure you quoted is its glycaemic endpoint, not a weight result.

Adding the obvious one — bring the export, not the single number, to whoever manages this.

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[removed]61 points·8 months ago

[removed by moderator]

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Type 2 diabetes as the original indication: A1c trajectories, CGM traces, hypoglycaemia risk when stacked with sulfonylureas or insulin, metformin combinations, and why the weight-loss conversation sometimes drowns out the glycaemic one.

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