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c/t2dglp1·submitted 10 months ago by u/zaid_dahlberg

how much of what we believe about CGM actually comes from T2D threads

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how much of what we believe about CGM actually comes from T2D threads. I am not trying to be the "source?" guy. I would just like a source. The three numbers, and what each one can and cannot tell you. A1c is an average over about three months, weighted to the recent weeks. It cannot show variability and it lags…

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6 comments, started 10 months ago
u/stubborn_batchlist_maybe15 points·10 months ago

Continuous monitoring shows the shape: postprandial excursions, overnight behaviour and time in range. Two people with identical A1c can have very different distributions.

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u/fasting_insulin_fMOD8 points·10 months ago

Retitled — the original quoted an obesity endpoint as a glycaemic one.

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[removed]6 points·10 months ago

[removed by moderator]

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u/jonas_cardoso12 points·10 months ago

That is a sensor value, not a plasma value, and the two are not interchangeable at that level of precision.

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u/hana_lehtinen4 points·10 months ago

Agreed. A1c is an integrated average over roughly three months and treating it as a current reading causes a lot of unnecessary alarm.

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u/swirl_dont_shakereconstitution2 points·10 months ago

Correction: that trial is the diabetes programme and the figure you quoted is its glycaemic endpoint, not a weight result.

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Type 2 diabetes as the original indication: A1c trajectories, CGM traces, hypoglycaemia risk when stacked with sulfonylureas or insulin, metformin combinations, and why the weight-loss conversation sometimes drowns out the glycaemic one.

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