4 months in and hepatic fat is still the thing I get wrong
4 months in and hepatic fat is still the thing I get wrong, logged the same way every week so the comparison is at least internally fair. The numbers the title promised, since a headline without them is worthless: 4 months. Everything below is context for those. It is a dual agonist at the GLP-1 and glucagon…
the weight numbers are secondary to what this is being developed for
That is an escalation schedule for an unapproved compound and this board does not host those.
Agreed. The hepatic programme is the point of this compound and the weight discussion is a side effect of the side effect.
Not convinced. Imaging-based fat fraction is not the same as a histological response and the paper is explicit about that.
fibrosis improvement without worsening steatohepatitis is the phrase to learn
Careful with the mechanism claim. Glucagon agonism is plausible as an explanation and it has not been isolated as the operative one.
Yes — histological endpoints are a far harder bar than the surrogate measures people are used to quoting.
Looked for independent results across this whole site and found almost none. Worth knowing before forming an opinion.
Careful with the mechanism claim.
Disagreeing with this bit: that number comes from a different programme with a different population.
Same. Very thin independent data on this one, which should make everybody here more tentative than they are.