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Single comment threadYou are looking at one branch of [Lab] 8th independent test on JEEP — 97.2% on a claimed 97.0%, and the trend is the interesting part — 24 comments in the full submission. View in context.
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c/survodutide·submitted 2 years ago by u/cormac_danquah

[Lab] 8th independent test on JEEP — 97.2% on a claimed 97.0%, and the trend is the interesting part

Trial Databranch of 8 comments

Result first, context after: 8th independent test on JEEP — 97.2% on a claimed 97.0%, and the trend is the interesting part . Everything below is how it was ordered, stored and sent. Numbers, in the order they matter: 97.2% and 97.0%. Histological endpoints in this field are scored on biopsy: resolution of…

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8 comments, started 2 years ago
u/julia_mensa36 points·2 years ago

Phase 2 in a biopsy-confirmed population is a demanding design: recruitment is slow, the population is specific, and the results do not generalise to people who have not been characterised that way.

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u/cold_chromatogram_only17 points·2 years ago

Phase 2 in a biopsy-confirmed population is a demanding design: recruitment is slow, the population is specific, and the results do not generalise to

julia_mensa is right that biopsy and imaging endpoints are not interchangeable.

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u/cormac_danquah7 points·2 years ago

That figure is from the obesity programme, and this thread is about the hepatic one.

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u/elin_tamm3 points·2 years ago

That figure is from the obesity programme, and this thread is about the hepatic one.

Agreed — and the endpoint definitions are where the actual claim lives.

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u/zeynep_villalobos1 point·2 years ago

Small fix — dual agonist, GLP-1 and glucagon. No GIP arm in this molecule.

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u/georgi_adebayo1 point·2 years ago

The escalation schedules in the published protocols are slow and deliberate, and the tolerability tables show why. That is a description of the trials rather than a suggestion for anybody.

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u/paper_trail_paulavetting1 point·2 years ago

What does the tolerability table say at that dose?

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u/chidi_demir4 points·2 years ago

This. Biopsy-confirmed and imaging-suggested are different evidentiary categories and get run together constantly.

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