[Paper] survodutide MASH data is the most interesting hepatic readout in the class
survodutide MASH data is the most interesting hepatic readout in the class. Change my mind, genuinely — I have no stake in being right about this.
Nothing containing this compound is approved anywhere. Research-use-only material is not approved for human use.
Imaging-derived liver fat fraction is a surrogate. It correlates with histology imperfectly, and a trial reporting one is not reporting the other.
Phase 2 in a biopsy-confirmed population is a demanding design: recruitment is slow, the population is specific, and the results do not generalise to people who have not been characterised that way.
Tell me where this is wrong. That is the useful part of posting it.
best — the order this archive was captured in
It is a dual agonist at the GLP-1 and glucagon receptors. The glucagon arm is associated with increased energy expenditure and with effects on hepatic fat, which is why the development programme is oriented towards liver disease.
not approved anywhere, and the boards forget that constantly
Assumed the weight numbers were the point and was corrected. They are secondary to what this is being developed for.
Sent a vial to Janoshik because there was nothing on file. 99.3% against a claimed 99.0%. First entry for this compound in my own log.
glucagon agonism and energy expenditure is the mechanistic thread
Small fix — dual agonist, GLP-1 and glucagon. No GIP arm in this molecule.
glucagon agonism and energy expenditure is the mechanistic thread
draw_up_dizzy is right that biopsy and imaging endpoints are not interchangeable.
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Which phase and which arm are you quoting?
Correction: that is the imaging endpoint, not the histological one. The paper reports both and they differ substantially.
This. Biopsy-confirmed and imaging-suggested are different evidentiary categories and get run together constantly.
Has anyone posted an independent purity result for this compound?
fibrosis improvement without worsening steatohepatitis is the phrase to learn
- 1glucagon agonism and energy expenditure is the mechanistic thread9 comments in this branch · started by u/draw_up_dizzy