[Results] 26 weeks on 1.7mg, full numbers, ask me anything boring
26 weeks on 1.7mg, full numbers, ask me anything boring. Full detail below, and I have tried to keep the editorialising out of it. To save the first four comments: 26 weeks and 1.7mg. The thing that surprised me was how much of the discussion here is inference rather than measurement. Kept a log specifically because…
Glucagon receptor agonism is associated with increased energy expenditure and with hepatic effects. That is a mechanistic story with strong preclinical support and limited phase 2 human data.
Left up. It reads the phase 2 paper carefully and it is honest about the intervals.
Yes — the comparison threads are apples to oranges and they generate more heat than anything else here.
comparing reta phase 2 to sema phase 3 is comparing different things
not approved anywhere, which is the single most important fact in this board
The phase 2 readout ran to 48 weeks in a few hundred participants with a slow escalation. Both the size and the duration matter when people quote the headline number.
Agreed on the heart-rate reports. They are consistent enough across the threads to be worth noting, not enough to be a finding.