[Results] 49 weeks, 7kg, and dose escalation was the hard part
49 weeks, 7kg, and dose escalation was the hard part. Numbers below. Ask me the boring questions, they are the useful ones. Numbers, in the order they matter: 49 weeks and 7kg. Where the evidence actually stands, since every thread here assumes a different answer. Phase 2 reported a large mean body weight change at…
Independent purity testing on this compound is thin compared with the older molecules, simply because fewer members have paid for it. Fewer results means wider uncertainty, not a verdict.
Trial names corrected in the title. The phase 3 programme and the phase 2 readout are not the same thing.
The thing that surprised me was how much of the discussion here is inference rather than measurement.
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Yes — the glucagon arm is what makes it a different proposition rather than a stronger version of the others.
That is body weight change, not fat mass. The trials report the first and people quote it as the second.
This. The phase 2 result was genuinely large and it was also 48 weeks in a few hundred people.
research-use-only material is not approved for human use, full stop
This.
nordic_pricing is right about the escalation being the variable. It explains most of the difficult reports here.
the phase 2 numbers were striking and they were also 48 weeks in a small population
phase 2 data only, and people quote it like it is a label
triple agonist — GLP-1, GIP and glucagon, and the glucagon arm is the new part