[Question] retatrutide — what am I missing here
retatrutide — what am I missing here — that is what I am asking, and I have already read the wiki twice.
Read the phase 2 paper twice before ordering anything. Recommend that to anyone in this board: the error bars are the interesting part.
Kept a log specifically because there is so little published. It is one person and it is not data.
The thing that surprised me was how much of the discussion here is inference rather than measurement.
Please do not ask me what dose you should be on. I genuinely do not know and neither does anyone else here.
best — the order this archive was captured in
Independent purity testing on this compound is thin compared with the older molecules, simply because fewer members have paid for it. Fewer results means wider uncertainty, not a verdict.
triple agonist — GLP-1, GIP and glucagon, and the glucagon arm is the new part
the glucagon component is why the metabolic story reads differently
phase 2 data only, and people quote it like it is a label
Small fix — three receptors, not two. GLP-1, GIP and glucagon, and the third one is the reason this compound gets its own board.
That reads as a titration plan for an unapproved compound. This board cannot host that and it should not want to.
the phase 2 numbers were striking and they were also 48 weeks in a small population
Correcting my own comment above: that figure was the 36-week interim, not the 48-week endpoint.
Is that the 48-week figure or an earlier readout?
Are you comparing against phase 3 numbers for something else? They are not comparable.
Removed the escalation schedule. There is no published protocol for members to follow and inventing one here is exactly what this board does not do.
Nothing containing this compound is approved anywhere. Research-use-only material is not approved for human use, and that is a statement of fact rather than a disclaimer.
Watched heart rate on a wearable across twelve weeks because the threads said to. It moved a little and I have no idea whether that means anything.
research-use-only material is not approved for human use, full stop
That is body weight change, not fat mass. The trials report the first and people quote it as the second.
a lot of the confident posting here is extrapolation
Which phase 2 arm are you quoting, and at what week?
small trial, big effect, wide error bars
- 1Removed the escalation schedule. There is no published protocol for members…8 comments in this branch · started by u/incretin_ivy
- 2That reads as a titration plan for an unapproved compound. This board cannot…6 comments in this branch · started by u/careful_gradient_notes