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Single comment threadYou are looking at one branch of the TRIUMPH thing finally clicked for me and I want to write it down — 24 comments in the full submission. View in context.
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c/retatrutide·submitted 1 year ago by u/heart_rate_bump

the TRIUMPH thing finally clicked for me and I want to write it down

Resultsbranch of 7 comments

The title is the argument: the TRIUMPH thing finally clicked for me and I want to write it down. Here is the rest of it. Independent purity testing on this compound is thin compared with the older molecules, simply because fewer members have paid for it. Fewer results means wider uncertainty, not a verdict. Nothing…

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This branch

7 comments, started 1 year ago
u/careful_gradient_again92 points·1 year ago

nothing here is available as a prescription product, so read every thread with that in mind

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u/endotoxin_elliemicro64 points·1 year ago

The thing that surprised me was how much of the discussion here is inference rather than measurement.

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[removed]46 points·1 year ago

[removed by moderator]

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u/noor_ivaturi24 points·1 year ago

the energy-expenditure story is mechanistically interesting and clinically unproven

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u/reflux_report19 points·1 year ago

Disagree. "More receptors means more effect" is not how any of this works and the trial data does not support the linear story.

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u/honest_syringe3318 points·1 year ago

the phase 2 numbers were striking and they were also 48 weeks in a small population

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u/priya_weiss12 points·1 year ago

Read the phase 2 paper twice before ordering anything. Recommend that to anyone in this board: the error bars are the interesting part.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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