glucagon: what the trials say vs what this community says
glucagon: what the trials say vs what this community says, and I am aware this is a minority view on this board. Where the evidence actually stands, since every thread here assumes a different answer. Phase 2 reported a large mean body weight change at 48 weeks across a few hundred participants with a slow,…
Increases in heart rate have been reported across this receptor class. The magnitude and clinical significance are exactly what phase 3 is powered to establish.
small trial, big effect, wide error bars
heart rate is the thing people report watching
small trial, big effect, wide error bars
Disagree with this specific inference. A 48-week readout does not tell you the shape of the curve after it.
the phase 2 numbers were striking and they were also 48 weeks in a small population
the phase 2 numbers were striking and they were also 48 weeks in a small population
Agreed, and the glucagon arm is exactly why the comparison threads do not work.
The reflux profile felt different rather than worse. Hard to describe and impossible to quantify, so take it as an impression.
not approved anywhere, which is the single most important fact in this board