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c/retatrutide·submitted 1 year ago by u/naomi_erdogan

TRIUMPH: what the trials say vs what this community says

Cautionbranch of 7 comments

TRIUMPH: what the trials say vs what this community says. It is the sort of thing everyone half-believes and nobody writes down. Went up slowly, deliberately, because everything on this board says the escalation is where trouble lives. Uneventful so far and I am not going to pretend that is a finding. The fatigue…

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7 comments, started 1 year ago
u/cagrilintide_enthusiast133 points·1 year ago

Nothing containing this compound is approved anywhere. Research-use-only material is not approved for human use, and that is a statement of fact rather than a disclaimer.

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u/noor_ivaturi86 points·1 year ago

Same read. The energy-expenditure mechanism is the interesting bit and it is not established in humans at scale.

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[deleted]61 points·1 year ago

[deleted]

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u/naomi_erdoganOP73 points·1 year ago

Small fix — three receptors, not two. GLP-1, GIP and glucagon, and the third one is the reason this compound gets its own board.

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u/jarno_cabrera54 points·1 year ago·edited

This. The phase 2 result was genuinely large and it was also 48 weeks in a few hundred people.

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u/mateusz_mensah12 points·1 year ago

Sceptical of the extrapolation. Forty-eight weeks does not tell you about seventy-two, and the curve shape is exactly what is unknown.

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u/lane_watchermod · logistics8 points·1 year ago

That is body weight change, not fat mass. The trials report the first and people quote it as the second.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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